ATSETILIN ASOSIDA OLINGAN FURAN KARBOSILIKAT HOSILALARINING BIOLOGIK FAOLLIGINI IN SILICO BAHOLASH

Nodirabegim Alimova

doi:10.66960/jof.3093-8899.00035

Authors

Nodirabegim Alimova magistr Author https://orcid.org/0009-0000-2872-3794

DOI:

https://doi.org/10.66960/jof.3093-8899.00035

Keywords:

2-furoic acid, vinyl ester of 2-furoic acid, vinyl acetate, vinyl exchange reaction, biological activity, PASS Online, molecular docking, in silico study, pharmacological potential, organic synthesis

Abstract

At present, the development of biologically active organic compounds and their synthesis using environmentally friendly and economically efficient methods represent one of the priority directions in organic chemistry and pharmaceutical science. In this study, vinyl esters of furan carboxylic acids were synthesized using vinyl acetate, and their physicochemical properties and biological activities were investigated. The biological activity of the synthesized compounds was predicted using the PASS Online platform, while their promising pharmacological properties were further evaluated by molecular docking analysis. The obtained results demonstrated that the synthesized compounds possess significant potential as biologically active molecules and may serve as promising candidates for the development of new pharmaceutical agents. Furthermore, the findings contribute to the advancement of organic synthesis and highlight the practical significance of these compounds for pharmaceutical applications.

Author Biography

Nodirabegim Alimova, magistr

Oʻzbekiston Milliy universiteti
Kimyo fakulteti

References

Kamiñski Z.J., Kolesiñska B, Małgorzata M. Mild and efficient synthesis of carboxylic acid anhydrides from carboxylic acids and triazine coupling reagents. Synth. Commun. -2004, –№ 34. –C. 3349–3358. DOI: https://doi.org/10.1081/SCC-200030581

A.Parmanov, S.Nurmanov, SH.Tursunov, O.Boytemirov, G.Xudiyarova. Tabiiy gazni qayta ishlash mahsuloti-vinilatsetat asosida vinil efirlar sintezi // Innovatsion texnika va texnologiyalarning qishloq xo‘jaligi ─ oziq-ovqat tarmog‘idagi muammo va istiqbollari mavzusidagi II-Xalqaro anjumani. 22-23-aprel. Toshkent Davlat texnika universiteti. Toshkent-2022. B.75-77.

Gutmann V. Solvent effects on the reactivities of organometallic compounds // Coordination chemistry reviews. –1976. – T. 18. -№. 2. – S. 225-255. DOI: https://doi.org/10.1016/S0010-8545(00)82045-7

Sangon S. et al. Direct comparison of safer or sustainable alternative dipolar aprotic solvents for use in carbon–carbon bond formation // Reaction chemistry & engineering. – 2020. – T. 5. – №. 9. – S. 1798-1804. DOI: https://doi.org/10.1039/D0RE00174K

G. S. KHUDIYAROVA, N. A. ALIMOVA, A. B. PARMANOV, S. KH. GANIEVA, S. E. NURMANOV SYNTHESIS AND BIOLOGICAL ACTIVITY ASSESSMENT OF VINYL ESTERS OF FURAN CARBOXYLIC ACID DERIVATIVES//UZBEK CHEMICAL JOURNAL. Aprel,2026 Tashkent. –P 58-68.

Ghatage S.L., Navale S.S., Mujawar N.K., Patil S., Patil V. Antimicrobial screening // Indian journal of drugs. -2014, -№. 2(3), -R. 84-88.

N.Alimova, G.Khudiyarova, S.Nurmanov, A.Parmanov. Biological activity of furan compounds: their effectiveness against cancer and bacterial infections, synthesis processes, and practical significance // Modern problems of theoretical and experimental chemistry. December 18-19, 2025 Baku, Azerbaijan. -P. 239.

Кобзев Е.Н., Петрикевич С.Б., Шкидченко А.Н. Исследование устойчивости ассоциации микроорганизмов-нефтедеструкторов в открытой системе // Прикладная биохимия и микробиология. -2001, -Т.37, №. 5. -С. 542-548.

Parmanov A.B., Nurmanov S.E., Mavloniy M.I., Maxkamov S. Vinil efirlarini neftni parchalovchi mikroorganizmlarga qarshi biologik faolligi // Res. konf. Kimyo va tibbiyot: nazariyadan amaliyotgacha. Buxoro davlat tibbiyot instituti. 7-8 oktabr, -2022. –B. 145-147.

Мавлоний М.И., Нурманов С.Э., Парманов А.Б. Ингибитори биокоррозии нефтепромислового оборудования // ДАН РУз. -2014, -№4. -С. 63-65.