ATSETILIN ASOSIDA OLINGAN FURAN KARBOSILIKAT HOSILALARINING BIOLOGIK FAOLLIGINI IN SILICO BAHOLASH

Nodirabegim Alimova

doi:10.66960/jof.3093-8899.00035

Mualliflar

Nodirabegim Alimova magistr Author https://orcid.org/0009-0000-2872-3794

DOI:

https://doi.org/10.66960/jof.3093-8899.00035

Kalit so‘zlar:

vinilatsetat, vinil almashinish reaksiyasi, biologik faollik, PASS Online, molekulyar docking, in silico tadqiqot, farmakologik potensial, organik sintez

Abstrakt

Hozirgi vaqtda biologik faol organik birikmalarni yaratish hamda ularni ekologik xavfsiz va iqtisodiy samarali usullar orqali sintez qilish organik kimyo va farmatsevtika sohalarining dolzarb yo‘nalishlaridan biridir. Ushbu tadqiqotda furan karbon kislotalari asosida vinil efirlari vinilatsetat ishtirokida sintez qilinib, ularning fizik-kimyoviy xossalari va biologik faolligi o‘rganildi. Biologik faollik PASS Online dasturi yordamida prognoz qilindi, istiqbolli farmakologik xususiyatlar esa molekulyar docking usuli orqali baholandi. Olingan natijalar sintez qilingan birikmalarning biologik faol moddalar sifatida istiqbolli ekanligini ko‘rsatdi hamda yangi dori vositalarini yaratish, organik sintezni rivojlantirish va farmatsevtika sanoatida qo‘llash uchun muhim ilmiy-amaliy ahamiyatga ega ekanligini tasdiqladi.

Muallif biografiyasi

Nodirabegim Alimova, magistr

Oʻzbekiston Milliy universiteti
Kimyo fakulteti

Havolalar

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